Department of Molecular Physiology


cAMP-gated channels
  • Ungerer, N., Mücke, N., Broecker, J., Keller, S., Frings, S., Möhrlen, F. (2011)
    Distinct binding properties distinguish LQ-type calmodulin-binding domains in cyclic nucleotide-gated channels
    Biochemistry    doi: /10.1021/bi200115m   
  • Waldeck, C., Vocke, K., Ungerer, N., Frings, S., Möhrlen, F. (2009)
    Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules
    Journal of General Physiology     134: 397-408   
  • Bradley, J., Reisert, J., Frings, S. (2005)
    Regulation of cyclic nucleotide-gated channels
    Current Opinion in Neurobiology 15: 343–349    Abstract     PDF

  • Bradley, J., Bönigk, W., Yau, K.-W. and Frings, S. (2004)
    Calmodulin permanently associates with rat olfactory CNG channels under native conditions
    Nature Neuroscience 7: 705-710     Abstract     PDF    News and Views

  • Bradley, J., Reuter, D., Frings, S. (2001)
    Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits.
    Science 294: 2176-2178     Abstract      Full Text     New nomenclature for cyclic nucleotide-gated channels       PDF

  • Ohyama, T., Hackos, D.H., Frings, S., Hagen, V., Kaupp, U.B., and J.I. Korenbrot (2000)
    Fraction of the dark current carried by Ca2+ through cGMP-gated ion channels of intact rod and cone photoreceptors.
    Journal of General Physiology 116: 735-753.     Abstract     PDF

  • Frings, S. (1999)
    Tuning Ca2+ permeation in cyclic nucleotide-gated channels.
    Journal of General Physiology 113: 795-797.     PDF

  • Dzeja, C., Hagen, V., Kaupp, U.B. and S. Frings (1999)
    Ca2+ permeation in cyclic nucleotide-gated channels.
    EMBO Journal 18: 131-144.     Abstract     PDF

  • Bönigk, W., Bradley, J., Müller, F., Sesti, F., Boekhoff, I., Ronnett, G.V., Kaupp, U.B. and S. Frings (1999)
    The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits.
    Journal of Neuroscience 19: 5332-5347     Abstract     PDF

  • Müller, F., Bönigk, W., Sesti, F. and S. Frings (1998)
    Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity.
    Journal of Neuroscience 18: 164-173.    Abstract     PDF

  • Frings, S. (1997)
    Cyclic nucleotide-gated channels and calcium: an intimate relation.
    In: Signal Transduction in Health and Disease: Advances in second messenger and phosphoprotein research. Corbin, J. and S. Francis eds. Lippincott-Raven, Philadelphia. pp. 75-82.

  • Hagen, V., Dzeja, C., Frings, S., Bendig, J., Krause, E. and U.B. Kaupp (1996)
    Caged compounds of hydrolysis-resistant analogues of cAMP and cGMP - synthesis and application to cyclic nucleotide-gated channels.
    Biochemistry 35: 7762-7771.    Abstract    PDF

  • Baumann, A., Frings, S., Koch, K.-W. and I. Weyand (1995)
    Signal transduction in vision and the chemical senses.
    Futura 10: 168-178.

  • Frings, S., Seifert, R., Godde, M. and U.B. Kaupp (1995)
    Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels.
    Neuron 15: 169-179.    Abstract   

  • Baumann, A., Frings, S., Godde, M., Seifert, R. and U.B. Kaupp (1994)
    Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present ineyes and antenna.
    EMBO Journal 13: 5040-5050.    Abstract

  • Weyand, I., Godde, M., Frings, S., Weiner, J., Müller, F., Altenhofen, W., Hatt, H. and U.B. Kaupp (1994)
    Cloning and functional expression of a cyclic nucleotide-gated channel from mammalian sperm.
    Nature 368: 859-863.    Abstract

  • Frings, S., Lynch, J. and B. Lindemann (1992)
    Properties of cyclic nucleotide-gated channels mediating olfactory transduction: activation by cyclic nucleotides, ion selectivity and channel blockage.
    Journal of General Physiology 100: 45-67.    Abstract    PDF

cAMP-gated channels

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