Toxins we use - Snake toxins & Conotoxins
Conotoxin is the venom of the cone shell
(„Kegelschnecke“). Some species of these marine snails are even
dangerous to humans (e.g. Conus textile, Conus geographus).
We also use snake toxins (Vipera nikolski, Agkistrodon saxatilis) to
examine their blocking effects on CNG-channels.
To specify the active compounds of these venoms, the
samples are fractionated repeatedly, whenever we find a fraction that
shows a blocking activity.
Finding a blocking fraction is very rare as you can
see in the table, where we tested 5 fractions from each of 19
species and only had one hit at Conus catus fraction 3. What makes the
„Toxfinder“-system very useful, is that it detects
animal-toxins with blocking effect fast and automatically.